Triple Olympic medallist Tori Bowie clocked a world-leading 22.09 in the 200m to highlight the Tom Jones Memorial Classic in Gainesville, Florida, on Friday (28).
The run, coming in her season's debut over the half lap, was the second fastest ever by Bowie, who took 100m silver, 200m bronze and 4x100m gold in Rio de Janeiro last August.
Bowie dominated the race, with world 400m leader Quanera Hayes a distant second in a lifetime best of 22.55.
There were strong early season sprint performances across the late afternoon programme.
Noah Lyles was equally dominant in the men's 200m, winning in 20.16, the second fastest of his young career, well clear of Portugal's David Lima and Olympic 400m hurdles champion Kerron Clement, who clocked 20.67 and 20.84 respectively.
Christopher Belcher, a student at North Carolina A&T University, won the 100m in 10.05, knocking 0.02 from his previous best. Keston Bledman and James Dasaolu were next across the line, each credited with 10.18. Another Briton, Harry Aikines-Aryeetey, clocked a wind-assisted 9.97 (3.3m/s) to win another heat.
On the women's side, two-time Olympic 200m champion Veronica Campbell-Brown of Jamaica notched a notable 100m debut, winning in 11.06 ahead of Kelly-Ann Baptiste who clocked 11.15.
Matthew Hudson-Smith won the men's 400m in 45.52. Jessica Beard took the women's race in 51.20.
Kyron McMasters, a world U20 bronze medallist in the 400m hurdles, won his specialty in 48.69, chipping 0.02 from his own British Virgin Islands national record.
Unheralded Devon Hill clocked 13.38 in the 110m hurdles, just shy of his 13.35 lifetime best set in 2012.
Belgian Anne Zagre won the women's 100m hurdles, clocking 12.96 in her season's debut.
On the infield, world indoor champion Marquis Dendy won the long jump with 8.13m and Darlan Romani of Brazil won the men's shot put with 20.93m.
Bob Ramsak for the IAAF